Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function.

ABSTRACT: Nuclear receptors are important bridges between lipid signaling molecules and transcription responses. Beside their role in several developmental and physiological processes, many of these receptors have been shown to regulate and determine the fate of immune cells, and the outcome of immune responses under physiological and pathological conditions. While NLRP3 inflammasome is assumed as key regulator for innate and adaptive immune responses, and has been associated with various pathological events, the precise impact of the nuclear receptors on the function of inflammasome is hardly investigated. A wide variety of factors and conditions have been identified as modulators of NLRP3 inflammasome activation, and at the same time, many of the nuclear receptors are known to regulate, and intera

SUBMITTER: Alatshan A 

PROVIDER: S-EPMC7952630 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature