The landscape of small cell lung cancer metastases: Organ specificity and timing.

ABSTRACT:

Background

Early metastasis is a hallmark of small cell lung cancer (SCLC). However, the mechanisms and resulting patterns of SCLC dissemination are unclear. Our aim was thus to investigate the organ specificity and timing of blood-borne metastases in a comprehensive large cohort of SCLC patients.

Methods

In this retrospective non-interventional cross-sectional study of 1009 Caucasian SCLC patients, we investigated the correlation between the distinct locations of the primary tumor and metastatic sites.

Results

The onset of bone (p < 0.001), brain (p < 0.001), and pericardial (p = 0.02) metastases were late events, whereas adrenal gland (p = 0.005) and liver (p < 0.001) metastases occurred earlier. No significant difference was found in the distribution of early versu

SUBMITTER: Megyesfalvi Z 

PROVIDER: S-EPMC7952793 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature