Rapid diagnostic test negative Plasmodium falciparum malaria in a traveller returning from Ethiopia.

ABSTRACT:

Background

Plasmodium falciparum strains with mutations/deletions of the genes encoding the histidine-rich proteins 2/3 (pfhrp2/3) have emerged during the last 10 years leading to false-negative results in HRP2-based rapid diagnostic tests (RDTs). This can lead to unrecognized infections in individuals and to setbacks in malaria control in endemic countries where RDTs are the backbone of malaria diagnostics and control.

Case description

Here the detection of a pfhrp2/3-negative P. falciparum infection acquired in Ethiopia by a 63-year old female traveller is presented. After onset of symptoms during travel, she was first tested negative for malaria, most probably by RDT, at a local hospital in Harar, Ethiopia. Falciparum malaria was finally diagnosed microscopically upon her

SUBMITTER: Schlabe S 

PROVIDER: S-EPMC7952815 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature