In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets.

ABSTRACT:

Background

The growing number of cases, severity and fatality of the COVID-19 pandemic, coupled with the fact that no cure has been found has made infected individuals especially in Africa, to resort to the consumption of different natural products to alleviate their condition. One of such plant materials that have been consumed to remedy the severity of this viral infection is the oil of Nigella sativa seed commonly called black seed oil. In this study, we extracted and characterized the oil from this seed using gas chromatography coupled to a mass selective detector to identify the component phytochemicals. Site-directed multiligand docking of the identified compounds was performed on SARS-CoV-2 molecular targets- Replicase polyprotein 1a, RNA binding protein of NSP9, ADP

SUBMITTER: Duru CE 

PROVIDER: S-EPMC7952832 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature