Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men.

ABSTRACT:

Objectives

Renal hyperfiltration (RHF) and fatty liver are separately associated with adverse health outcomes. In this study, we investigated the mortality hazard of coexisting RHF and fatty liver.

Methods

Middle-aged men from the Kuopio Ischaemic Disease Risk Factor Study (n=1,552) were followed up for a median of 29 years. Associations among RHF, fatty liver index (FLI) score, age, body mass index, smoking status, alcohol consumption, and hypertension status were assessed using logistic regression. Cox proportional hazards models were used to determine the hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality with respect to RHF and fatty liver.

Results

Of the men, 5% had RHF (n=73), whereas a majority had fatty liver (n=848). RHF was associat

SUBMITTER: Ould Setti M 

PROVIDER: S-EPMC7952838 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature