Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease.

ABSTRACT: The development of a non-sputum-based, point-of-care diagnostic test for tuberculosis (TB) is a priority in the global effort to combat this disease, particularly in resource-constrained settings. Previous studies have identified host biomarker signatures which showed potential, but there is a need to validate and refine these for development as a test. We recruited 1,403 adults presenting with symptoms suggestive of pulmonary TB at primary healthcare clinics in six countries from West, East and Southern Africa. Of the study cohort, 326 were diagnosed with TB and 787 with other respiratory diseases, from whom we randomly selected 1005 participants. Using Luminex^® technology, we measured the levels of 20 host biomarkers in serum samples which we used to evaluate the diagnostic ac

SUBMITTER: Mutavhatsindi H 

PROVIDER: S-EPMC7952865 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature