Prognostic and Predictive Value of m6A "Eraser" Related Gene Signature in Gastric Cancer.

ABSTRACT:

Background

N6-methyladenosine (m6A) RNA modification plays a critical role in gastric cancer (GC). However, the relationship between the m6A "eraser", FTO, and ALKBH5, and the prognosis of GC still remains unclear. This study aimed to evaluate the effect of FTO and ALKBH5 on the prognosis of patients and their potential roles in GC.

Materials and methods

A total of 738 GC samples with clinical information obtained from two independent datasets were included and divided into training set and testing set. Differential expression analysis of the m6A "eraser" related genes was performed. The LASSO Cox regression model was constructed to analyze the m6A "eraser" related risk genes. The univariate and multivariate Cox regression model were employed to identify the independent prog

SUBMITTER: Xu X 

PROVIDER: S-EPMC7952866 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature