Analysis of the Characteristics of TIGIT-Expressing CD3^-CD56⁺NK Cells in Controlling Different Stages of HIV-1 Infection.

ABSTRACT: TIGIT expression on natural killer (NK) cells is associated with dysfunction during chronic HIV infection, but the phenotype and biological functions of these cells in the context of acute HIV-1 infection remain poorly understood. Here, 19 acutely infected HIV-1 patients traced at first, third and twelfth month, and age-matched patients with chronic HIV-1 infection were enrolled to investigate the phenotype and functions of TIGIT expression on NK cells. We found that TIGIT-expressing NK cells did not increase in frequency in the first, third and twelfth month of infection until chronic HIV-1 infection lasted over 2 years. The number of TIGIT⁺NK cells in acute infection was positively associated with HIV-1 viral load (r = 0.53, P = 0.0009). CD96 was significantly up

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7953050 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature