Ovarian adenocarcinoma with metastases in a white rhinoceros.

ABSTRACT: A 36-y-old white rhinoceros (Ceratotherium simum) was presented with respiratory distress, sanguineous vaginal exudate, and anorexia. The clinical signs progressed over 40 d, and the rhinoceros died. Autopsy revealed significant ascites; a unilateral, 12.5-cm diameter, polypoid mass in the left ovary; a white, firm transmural mass in the right uterine horn; a white, friable mass in the lung; and white-to-tan, friable small nodules in the diaphragm. Histologic examination revealed similar neoplastic cells in the masses in all 4 locations, composed predominantly of epithelial cells proliferating in a tubulopapillary pattern with significant nuclear atypia and numerous atypical mitotic figures (18-42 per 2.37 mm²). Immunohistochemistry for CK7 (cytokeratin 7) and CK20 (cytok

SUBMITTER: Kim SH 

PROVIDER: S-EPMC7953103 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature