Associations of self-reported obstructive sleep apnea with total and site-specific cancer risk in older women: a prospective study.

ABSTRACT:

Background and objectives

Chronic intermittent hypoxia resulting from obstructive sleep apnea (OSA) may activate multiple carcinogenic pathways and lead to cancer development.

Methods

We prospectively examined the association between OSA and cancer risk among 65,330 women in the Nurses' Health Study who were free of cancer in 2008 (mean age: 73.3 years). Incident cancer diagnoses were collected until 2016 and confirmed by pathology reports. Clinically diagnosed OSA was self-reported in 2008 and updated in 2012. We used time-dependent Cox regression to estimate hazard ratios (HR) for the associations of OSA with total and site-specific cancer risk.

Results

We documented 5,257 incident cancer diagnoses during follow-up. In the age-adjusted model, OSA was associated with

SUBMITTER: Huang T 

PROVIDER: S-EPMC7953220 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature