Association Between Prehospital Tranexamic Acid Administration and Outcomes of Severe Traumatic Brain Injury.

ABSTRACT:

Importance

The development and expansion of intracranial hematoma are associated with adverse outcomes. Use of tranexamic acid might limit intracranial hematoma formation, but its association with outcomes of severe traumatic brain injury (TBI) is unclear.

Objective

To assess whether prehospital administration of tranexamic acid is associated with mortality and functional outcomes in a group of patients with severe TBI.

Design, setting, and participants

This multicenter cohort study is an analysis of prospectively collected observational data from the Brain Injury: Prehospital Registry of Outcome, Treatments and Epidemiology of Cerebral Trauma (BRAIN-PROTECT) study in the Netherlands. Patients treated for suspected severe TBI by the Dutch Helicopter Emergency Medical

SUBMITTER: Bossers SM 

PROVIDER: S-EPMC7953275 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature