The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans.

ABSTRACT: Deep brain stimulation (DBS) is used to treat a wide array of neurologic conditions. However, traditional programming of stimulation parameters relies upon short term subjective observation of patient symptoms and undesired stimulation effects while in the clinic. To gain a more objective measure of the neuronal activity that contributes to patient symptoms and response to treatment, there is a clear need for a fully-implantable DBS system capable of chronically recording patient-specific electrophysiological biomarker signals over time. By providing an objective correlate of a patient's disease and response to treatment, this capability has the potential to improve therapeutic benefit while preventing undesirable side effects. Herein, the engineering and capabilities of the Percept PC, th

SUBMITTER: Goyal A 

PROVIDER: S-EPMC7953342 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature