Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma (CCA) represents a rare but highly aggressive malignancy that is often challenging to diagnose, especially in early stages. The role of existing tumor biomarkers for CCA diagnosis, remains controversial due to their low sensitivity and specificity. Increasing evidence has implicated long non-coding ribonucleic acid polymorphisms with cancer susceptibility in a variety of tumor types. The association between long non-coding ribonucleic acid homeobox protein transcript antisense intergenic ribonucleic acid (HOTAIR) polymorphisms and CCA risk has not been reported yet.

Aim

To investigate the influence of HOTAIR variants on the risk of CCA development.

Methods

We conducted a case-control study in which three HOTAIR single nucleotide polymorph

SUBMITTER: Lampropoulou DI 

PROVIDER: S-EPMC7953393 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature