Bis[pyrrolyl Ru(ii)] triads: a new class of photosensitizers for metal-organic photodynamic therapy.

ABSTRACT: A new family of ten dinuclear Ru(ii) complexes based on the bis[pyrrolyl Ru(ii)] triad scaffold, where two Ru(bpy)₂ centers are separated by a variety of organic linkers, was prepared to evaluate the influence of the organic chromophore on the spectroscopic and in vitro photodynamic therapy (PDT) properties of the compounds. The bis[pyrrolyl Ru(ii)] triads absorbed strongly throughout the visible region, with several members having molar extinction coefficients (ε) ≥ 10⁴ at 600-620 nm and longer. Phosphorescence quantum yields (Φ _p) were generally less than 0.1% and in some cases undetectable. The singlet oxygen quantum yields (Φ _Δ) ranged from 5% to 77% and generally correlated with their photocytotoxicities toward hu

SUBMITTER: Smithen DA 

PROVIDER: S-EPMC7953431 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature