Ontology highlight
ABSTRACT:
SUBMITTER: Cribbs AP
PROVIDER: S-EPMC7953504 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Cribbs Adam P AP Filippakopoulos Panagis P Philpott Martin M Wells Graham G Penn Henry H Oerum Henrik H Valge-Archer Viia V Feldmann Marc M Oppermann Udo U
Frontiers in immunology 20210226
Natural killer (NK) cells are innate lymphocytes that play a pivotal role in the immune surveillance and elimination of transformed or virally infected cells. Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BRD4 as central regulators of NK cell functions, including direct cytokine secretion, NK cell contact-dependent inflammatory cytokine secretion from monocytes as well as NK cell cytolytic functions. We show that both BRD2 and BRD4 control inflammatory ...[more]