X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals.

ABSTRACT:

Background

Stroke is a sexually dimorphic disease. Previous studies have found that young females are protected against ischemia compared to males, partially due to the protective effect of ovarian hormones, particularly estrogen (E₂). However, there are also genetic and epigenetic effects of X chromosome dosage that contribute to stroke sensitivity and neuroinflammation after injury, especially in the aged. Genes that escape from X chromosome inactivation (XCI) contribute to sex-specific phenotypes in many disorders. Kdm5c and kdm6a are X escapee genes that demethylate H3K4me3 and H3K27me3, respectively. We hypothesized that the two demethylases play critical roles in mediating the stroke sensitivity.

Methods

To identify the X escapee genes involved in stroke, we

SUBMITTER: Qi S 

PROVIDER: S-EPMC7953638 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature