A novel preference-informed complementary trial (PICT) design for clinical trial research influenced by strong patient preferences.

ABSTRACT:

Background

Patients and their families often have preferences for medical care that relate to wider considerations beyond the clinical effectiveness of the proposed interventions. Traditionally, these preferences have not been adequately considered in research. Research questions where patients and families have strong preferences may not be appropriate for traditional randomized controlled trials (RCTs) due to threats to internal and external validity, as there may be high levels of drop-out and non-adherence or recruitment of a sample that is not representative of the treatment population. Several preference-informed designs have been developed to address problems with traditional RCTs, but these designs have their own limitations and may not be suitable for many research questio

SUBMITTER: Ali S 

PROVIDER: S-EPMC7953803 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature