HiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice.

ABSTRACT:

Background

Spinal cord injury (SCI) is a common disease that results in motor and sensory disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), or subsequently generated stem/progenitor cells, is predicted to be a promising treatment for SCI. In this study, we aimed to investigate effect of human iPSC-derived neural stem cells (hiPSC-NSCs) and umbilical cord-derived MSCs (huMSCs) in a mouse model of acute SCI.

Methods

Acute SCI mice model were established and were randomly treated as phosphate-buffered saline (PBS) (control group), repaired with 1 × 10⁵ hiPSC-NSCs (NSC group), and 1 × 10⁵ huMSCs (MSC group), respectively, in a

SUBMITTER: Kong D 

PROVIDER: S-EPMC7953804 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature