Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC7953940 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Clinical immunology (Orlando, Fla.) 20180824
IL-11 induced differentiation and expansion of Th17 cells in patients with early relapsing-remitting multiple sclerosis (RRMS). In mice with relapsing-remitting experimental autoimmune encephalomyelitis (RREAE), IL-11 exacerbated disease, induced demyelination in the central nervous system (CNS), increased the percentage of IL-17A<sup>+</sup>CD4<sup>+</sup> Th17 cells in the CNS in the early acute phase, and up-regulated serum IL-17A levels and the percentage of IL-17A<sup>+</sup>CD4<sup>+</sup> ...[more]