Disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition.

ABSTRACT:

Background

Hippocampal oscillations play a critical role in the ontogeny of allocentric memory in rodents. During the critical period for memory development, hippocampal theta is the driving force behind the temporal coordination of neuronal ensembles underpinning spatial memory. While known that hippocampal oscillations are necessary for normal spatial cognition, whether disrupted hippocampal oscillatory activity during the critical period impairs long-term spatial memory is unknown. Here we investigated whether disruption of normal hippocampal rhythms during the critical period have enduring effects on allocentric memory in rodents.

Objective/hypothesis

We hypothesized that disruption of hippocampal oscillations via artificial regulation of the medial septum during the cri

SUBMITTER: Kloc ML 

PROVIDER: S-EPMC7953993 | biostudies-literature | 2020 Nov - Dec

REPOSITORIES: biostudies-literature