Novel exposure biomarkers of N,N-diethyl-m-toluamide (DEET): Data from the 2007-2010 National Health and Nutrition Examination Survey.

ABSTRACT:

Background

N,N-diethyl-m-toluamide (DEET) is a widely used insect repellent in the United States.

Objectives

To assess exposure to DEET in a representative sample of persons 6years and older in the U.S. general population from the 2007-2010 National Health and Nutrition Examination Survey.

Methods

We analyzed 5348 urine samples by using online solid-phase extraction coupled to isotope dilution-high-performance liquid chromatography-tandem mass spectrometry. We used regression models to examine associations of various demographic parameters with urinary concentrations of DEET biomarkers.

Results

We detected DEET in ~3% of samples and at concentration ranges (>0.08μg/L-45.1μg/L) much lower than those of 3-(diethylcarbamoyl)benzoic acid (DCBA) (>0.48μg/L-30,400μg/

SUBMITTER: Calafat AM 

PROVIDER: S-EPMC7953995 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature