Systematic analysis of long intergenic non-coding RNAs in C. elegans germline uncovers roles in somatic growth.

ABSTRACT: Long intergenic non-coding RNAs (lincRNAs) are transcripts longer than 200 nucleotides that are transcribed from non-coding loci yet undergo biosynthesis similar to coding mRNAs. The disproportional number of lincRNAs expressed in testes suggests that lincRNAs are important during gametogenesis, but experimental evidence has implicated very few lincRNAs in this process. We took advantage of the relatively limited number of lincRNAs in the genome of the nematode Caenorhabditis elegans to systematically analyse the functions of lincRNAs during meiosis. We deleted six lincRNA genes that are highly and dynamically expressed in the C. elegans gonad and tested the effects on central meiotic processes. Surprisingly, whereas the lincRNA deletions did not strongly impact fertility, ge

SUBMITTER: Ishtayeh H 

PROVIDER: S-EPMC7954028 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature