Severe OSA associated with higher risk of mortality in stage III and IV lung cancer.

ABSTRACT:

Study objectives

OSA has been associated with increased cancer incidence and mortality. The aim of this study was to investigate cancer-related mortality, overall survival, and progression-free survival in patients with suspected OSA and lung cancer.

Methods

This was a case series analysis of lung cancer from a sleep cohort with suspected OSA between 2009 and 2014. The AHI, hypoxia index, and survival outcome were recorded. Immunohistochemistry was used to analyze hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor expression in tumor pathology.

Results

In the sleep cohort comprising 8,261 patients, a total of 23 patients had lung cancer. The incidence of lung cancer was significantly higher in the sleep cohort than in the entire adult populati

SUBMITTER: Huang HY 

PROVIDER: S-EPMC7954049 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature