[¹⁸F]-FDHT PET/CT as a tool for imaging androgen receptor expression in high-grade glioma.

ABSTRACT:

Background

G lioblastoma (GBM) is associated with poor overall survival. Recently, we showed that androgen receptor (AR) protein is overexpressed in 56% of GBM specimens and AR antagonists induced dose-dependent death in several GBM cell lines and significantly reduced tumor growth and prolonged the lifespan of mice implanted with human GBM. 16β-18F-fluoro-5α-dihydrotestosterone ([¹⁸F]-FDHT) is a positron emission tomography (PET) tracer used to detect AR expression in prostate and breast cancers. This study was aimed at exploring the ability of [¹⁸F]-FDHT-PET to detect AR expression in high-grade gliomas.

Methods

Twelve patients with suspected high-grade glioma underwent a regular workup and additional dynamic and static [¹⁸F]-FDHT-PET/CT. V

SUBMITTER: Orevi M 

PROVIDER: S-EPMC7954111 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature