Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model.

ABSTRACT: Leishmania major is the main causative agent of cutaneous leishmaniasis in the Old World. In Leishmania parasites, the lack of transcriptional control is mostly compensated by post-transcriptional mechanisms. Methylation of arginine is a conserved post-translational modification executed by Protein Arginine Methyltransferase (PRMTs). The genome from L. major encodes five PRMT homologs, including the cytosolic protein associated with several RNA-binding proteins, LmjPRMT7. It has been previously reported that LmjPRMT7 could impact parasite infectivity. In addition, a more recent work has clearly shown the importance of LmjPRMT7 in RNA-binding capacity and protein stability of methylation targets, demonstrating the role of this enzyme as an important epigenetic regulator of mRNA metabolism.

SUBMITTER: Alcoforado Diniz J 

PROVIDER: S-EPMC7954300 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature