The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study.

ABSTRACT:

Background

Insulin resistance predisposes to cardiometabolic disorders, which are commonly comorbid with schizophrenia and are key contributors to the significant excess mortality in schizophrenia. Mechanisms for the comorbidity remain unclear, but observational studies have implicated inflammation in both schizophrenia and cardiometabolic disorders separately. We aimed to examine whether there is genetic evidence that insulin resistance and 7 related cardiometabolic traits may be causally associated with schizophrenia, and whether evidence supports inflammation as a common mechanism for cardiometabolic disorders and schizophrenia.

Methods and findings

We used summary data from genome-wide association studies of mostly European adults from large consortia (Meta-Analyses of G

SUBMITTER: Perry BI 

PROVIDER: S-EPMC7954314 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature