Disrupted basal ganglia-thalamocortical loops in focal to bilateral tonic-clonic seizures.

ABSTRACT: Focal to bilateral tonic-clonic seizures are associated with lower quality of life, higher risk of seizure-related injuries, increased chance of sudden unexpected death, and unfavourable treatment outcomes. Achieving greater understanding of their underlying circuitry offers better opportunity to control these seizures. Towards this goal, we provide a network science perspective of the interactive pathways among basal ganglia, thalamus and cortex, to explore the imprinting of secondary seizure generalization on the mesoscale brain network in temporal lobe epilepsy. Specifically, we parameterized the functional organization of both the thalamocortical network and the basal ganglia-thalamus network with resting state functional MRI in three groups of patients with different focal to bilatera

SUBMITTER: He X 

PROVIDER: S-EPMC7954388 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature