Frequency of Complicated Symptomatic Bone Metastasis Over a Breadth of Operational Definitions.

ABSTRACT:

Purpose

Numerous randomized trials have demonstrated noninferiority of single- versus multiple-fraction palliative radiation therapy (RT) in the management of uncomplicated bone metastases; yet there is neither a clear definition of what constitutes a complicated lesion, nor substantial data regarding the prevalence of such complicating features in clinical practice. Thus, we identify a range of evidence-based operational definitions of complicated symptomatic bone metastases and characterize the frequency of such complicating features at a high-volume, tertiary care center.

Methods and materials

A retrospective review of patients seen in consultation for symptomatic bone metastases between March 1, 2007, and July 31, 2013, at Johns Hopkins Hospital identified patient and di

SUBMITTER: Alcorn SR 

PROVIDER: S-EPMC7954524 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature