Health-related quality of life after Gamma Knife radiosurgery in patients with 1-10 brain metastases.

ABSTRACT:

Purpose

Increasingly more patients with multiple (> 4) brain metastases (BM) are being treated with stereotactic radiosurgery (SRS). Preserving patients' health-related quality of life (HRQoL) is an important treatment goal. The aim of this study was to assess (individual) changes in HRQoL in patients with 1-10 BM over time.

Methods

A total of 92 patients were assessed before (n = 92) and at 3 (n = 66), 6 (n = 53), and 9 (n = 41) months after Gamma Knife radiosurgery (GKRS), using the Functional Assessment of Cancer Therapy-Brain (FACT-Br). The course of HRQoL was analyzed using linear mixed models. Clinical minimally important differences were used to evaluate individual changes.

Results

At group level, patients' physical well-being worsened, whereas emotional well-b

SUBMITTER: Verhaak E 

PROVIDER: S-EPMC7954744 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature