SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice.

ABSTRACT:

Background

Cardiovascular diseases (CVDs) and diabetes mellitus (DM) are top two chronic comorbidities that increase the severity and mortality of COVID-19. However, how SARS-CoV-2 alters the progression of chronic diseases remain unclear.

Methods

We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice. SARS-CoV-2's impacts on pathogenesis of chronic diseases were studied through histopathological, virologic and molecular biology analysis.

Results

Pre-existing CVDs resulted in viral invasion, ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection. Viral infection increased fasting blood glucose and reduced insulin response in DM model. Bone mineral density decreased shortly after infectio

SUBMITTER: Ma Y 

PROVIDER: S-EPMC7954823 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature