Long-term lymphoid progenitors independently sustain naive T and NK cell production in humans.

ABSTRACT: Our mathematical model of integration site data in clinical gene therapy supported the existence of long-term lymphoid progenitors capable of surviving independently from hematopoietic stem cells. To date, no experimental setting has been available to validate this prediction. We here report evidence of a population of lymphoid progenitors capable of independently maintaining T and NK cell production for 15 years in humans. The gene therapy patients of this study lack vector-positive myeloid/B cells indicating absence of engineered stem cells but retain gene marking in both T and NK. Decades after treatment, we can still detect and analyse transduced naïve T cells whose production is likely maintained by a population of long-term lymphoid progenitors. By tracking insertional clonal markers

SUBMITTER: Izotova N 

PROVIDER: S-EPMC7954865 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature