Tendon Multiscale Structure, Mechanics, and Damage Are Affected by Osmolarity of Bath Solution.

ABSTRACT: One of the most common bath solutions used in musculoskeletal mechanical testing is phosphate buffered saline (PBS). In tendon, swelling induced by physiological PBS results in decreased tendon modulus and induces microstructural changes. It is critical to evaluate the multiscale mechanical behavior of tendon under swelling to interpret prior work and provide information to design future studies. We compared the effects of physiological PBS and 8% polyethylene glycol and saline bathing solutions on tendon multiscale tendon mechanics and damage as well as microstructure with TEM in order to understand the effect of swelling on tendon. At the tissue level, tendons in PBS had a lower modulus than SPEG samples. PBS samples also showed an increased amount of non-recoverable sliding, which is an

SUBMITTER: Bloom ET 

PROVIDER: S-EPMC7954897 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature