White matter tracts related to memory and emotion in very preterm children.

ABSTRACT:

Background

Very preterm (VP) children are at risk of memory and emotional impairments; however, the neural correlates remain incompletely defined. This study investigated the effect of VP birth on white matter tracts traditionally related to episodic memory and emotion.

Methods

The cingulum, fornix, uncinate fasciculus, medial forebrain bundle and anterior thalamic radiation were reconstructed using tractography in 144 VP children and 33 full-term controls at age 7 years.

Results

Compared with controls, VP children had higher axial, radial, and mean diffusivities and neurite orientation dispersion, and lower volume and neurite density in the fornix, along with higher neurite orientation dispersion in the medial forebrain bundle. Support vector classification models ba

SUBMITTER: Kelly CE 

PROVIDER: S-EPMC7954988 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature