Ketone body 3-hydroxybutyrate as a biomarker of aggression.

ABSTRACT: Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using ¹H nuclear magnetic resonance spectroscopy. We used a discovery sample of young adults and an independent adult replication sample. We studied 725 young adults from a population-based Finnish twin cohort born 1983-1987, with aggression levels rated in adolescence (ages 12, 14, 17) by multiple raters and blood plasma samples at age 22. Linear regression models specified metabolites as the response variable and aggression ratings as predictor variables, and included several potential confounders. All metabolites showe

SUBMITTER: Whipp AM 

PROVIDER: S-EPMC7955062 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature