Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams.

ABSTRACT: Proton therapy allows to avoid excess radiation dose on normal tissues. However, there are some limitations. Indeed, passive delivery of proton beams results in an increase in the lateral dose upstream of the tumor and active scanning leads to strong differences in dose delivery. This study aims to assess possible differences in the transcriptomic response of skin in C57BL/6 mice after TBI irradiation by active or passive proton beams at the dose of 6 Gy compared to unirradiated mice. In that purpose, total RNA was extracted from skin samples 3 months after irradiation and RNA-Seq was performed. Results showed that active and passive delivery lead to completely different transcription profiles. Indeed, 140 and 167 genes were differentially expressed after active and passive scanning compar

SUBMITTER: Leduc A 

PROVIDER: S-EPMC7955113 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature