Discovery of fungal surface NADases predominantly present in pathogenic species.
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ABSTRACT:
SUBMITTER: Stromland O
PROVIDER: S-EPMC7955114 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Discovery of fungal surface NADases predominantly present in pathogenic species.
Strømland Øyvind Ø Kallio Juha P JP Pschibul Annica A Skoge Renate H RH Harðardóttir Hulda M HM Sverkeli Lars J LJ Heinekamp Thorsten T Kniemeyer Olaf O Migaud Marie M Makarov Mikhail V MV Gossmann Toni I TI Brakhage Axel A AA Ziegler Mathias M
Nature communications 20210312 1
Nicotinamide adenine dinucleotide (NAD) is a key molecule in cellular bioenergetics and signalling. Various bacterial pathogens release NADase enzymes into the host cell that deplete the host's NAD<sup>+</sup> pool, thereby causing rapid cell death. Here, we report the identification of NADases on the surface of fungi such as the pathogen Aspergillus fumigatus and the saprophyte Neurospora crassa. The enzymes harbour a tuberculosis necrotizing toxin (TNT) domain and are predominately present in ...[more]
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