Gut-Ex-Vivo system as a model to study gluten response in celiac disease.

ABSTRACT: Celiac disease (CD) is a complex immune-mediated chronic disease characterized by a consistent inflammation of the gastrointestinal tract induced by gluten intake in genetically predisposed individuals. Although initiated by the interaction between digestion-derived gliadin, a gluten component, peptides, and the intestinal epithelium, the disorder is highly complex and involving other components of the intestine, such as the immune system. Therefore, conventional model systems, mainly based on two- or three-dimension cell cultures and co-cultures, cannot fully recapitulate such a complex disease. The development of mouse models has facilitated the study of different interacting cell types involved in the disorder, together with the impact of environmental factors. However, such in vivo mod

SUBMITTER: Gagliardi M 

PROVIDER: S-EPMC7955131 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature