Femaleless Controls Sex Determination and Dosage Compensation Pathways in Females of Anopheles Mosquitoes.

ABSTRACT: The insect sex determination and the intimately linked dosage compensation pathways represent a challenging evolutionary puzzle that has been solved only in Drosophila melanogaster. Analyses of orthologs of the Drosophila genes identified in non-drosophilid taxa^1,2 revealed that evolution of sex determination pathways is consistent with a bottom-up mode,³ where only the terminal genes within the pathway are well conserved. doublesex (dsx), occupying a bottom-most position and encoding sex-specific proteins orchestrating downstream sexual differentiation processes, is an ancient sex-determining gene present in all studied species.^2,4,5 With the exception of lepidopterans, its female-specific s

SUBMITTER: Krzywinska E 

PROVIDER: S-EPMC7955153 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature