Temporal Associations Among Body Mass Index, Fasting Insulin, and Systemic Inflammation: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Obesity is associated with a number of noncommunicable chronic diseases and is purported to cause premature death.

Objective

To summarize evidence on the temporality of the association between higher body mass index (BMI) and 2 potential mediators: chronic inflammation and hyperinsulinemia.

Data sources

MEDLINE (1946 to August 20, 2019) and Embase (from 1974 to August 19, 2019) were searched, although only studies published in 2018 were included because of a high volume of results. The data analysis was conducted between January 2020 and October 2020.

Study selection and measures

Longitudinal studies and randomized clinical trials that measured fasting insulin level and/or an inflammation marker and BMI with at least 3 commensurate time points were s

SUBMITTER: Wiebe N 

PROVIDER: S-EPMC7955272 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature