Mitochondrial DNA Content Is Linked to Cardiovascular Disease Patient Phenotypes.

ABSTRACT: Background We sought to determine whether mitochondrial DNA (mtDNA) content can be used as markers for 12 key phenotypes among cardiovascular disease patients, and whether these markers are valid across patients with diverse ancestries. Methods and Results DNA was collected from the peripheral blood of 996 cardiovascular disease patients at the Cleveland Clinic. The mtDNA copy number and DNA-level variation were assessed from whole-genome sequence. Patients were also ascertained retrospectively for histories of 10 clinical events, as well as for maximum stenosis and extent of disease at baseline. Self-reported race and maternal ancestry inferred from mtDNA sequence were recorded. MtDNA copy number and overall mtDNA rare variant load were significantly lower in patients with histories of va

SUBMITTER: Wei R 

PROVIDER: S-EPMC7955324 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature