Refining Safe Contrast Limits for Preventing Acute Kidney Injury After Percutaneous Coronary Intervention.

ABSTRACT: Background Contrast-associated acute kidney injury (CA-AKI) is associated with substantial morbidity and may be prevented by using less contrast during percutaneous coronary intervention (PCI). However, tools for determining safe contrast volumes are limited. We developed risk models to tailor safe contrast volume limits during PCI. Methods and Results Using data from all PCIs performed at 18 hospitals from January 2015 to March 2018, we developed logistic regression models for predicting CA-AKI, including simpler models ("pragmatic full," "pragmatic minimum") using only predictors easily derivable from electronic health records. We prospectively validated these models using PCI data from April 2018 to December 2018 and compared them to preexisting safe contrast models using the area under

SUBMITTER: Yuan N 

PROVIDER: S-EPMC7955500 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature