Characterization of the first vaginal Lactobacillus crispatus genomes isolated in Brazil.

ABSTRACT:

Background

Lactobacillus crispatus is the dominant species in the vaginal microbiota associated with health and considered a homeostasis biomarker. Interestingly, some strains are even used as probiotics. However, the genetic mechanisms of L. crispatus involved in the control of the vaginal microbiome and protection against bacterial vaginosis (BV) are not entirely known. To further investigate these mechanisms, we sequenced and characterized the first four L. crispatus genomes from vaginal samples from Brazilian women and used genome-wide association study (GWAS) and comparative analyses to identify genetic mechanisms involved in healthy or BV conditions and selective pressures acting in the vaginal microbiome.

Methods

The four genomes were sequenced, a

SUBMITTER: Oliveira de Almeida M 

PROVIDER: S-EPMC7955673 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature