Updates on Genes and Genetic Mechanisms Implicated in Primary Angle-Closure Glaucoma.

ABSTRACT: Primary angle-closure glaucoma (PACG) is estimated to affect over 30 million people worldwide by 2040 and is highly prevalent in the Asian population. PACG is more severe and carries three times the higher risk of blindness than primary open-angle glaucoma, thus representing a significant public health concern. High heritability and ethnic-specific predisposition to PACG suggest the involvement of genetic factors in disease development. In the recent past, genetic studies have led to the successful identification of several genes and loci associated with PACG across different ethnicities. The precise cellular and molecular roles of these multiple loci in the development and progression of PACG remains to be elucidated. Nonetheless, these studies have significantly increased our understandi

SUBMITTER: Kondkar AA 

PROVIDER: S-EPMC7955727 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature