Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine.

ABSTRACT:

Purpose

It has been suggested that reward system dysfunction may account for emotion and pain suffering in migraine. However, there is a lack of evidence whether the altered reward system connectivity is directly associated with clinical manifestations, including negative affect and ictal pain severity and, at the molecular level, the dopamine (DA) D2/D3 receptors (D2/3Rs) signaling implicated in encoding motivational and emotional cues.

Patients and methods

We acquired resting-state functional MRI from interictal episodic migraine (EM) patients and age-matched healthy controls, as well as positron emission tomography (PET) with [¹¹C]raclopride, a selective radiotracer for DA D2/3Rs, from a subset of these participants. The nucleus accumbens (NAc) was seeded to me

SUBMITTER: Kim DJ 

PROVIDER: S-EPMC7955762 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature