Semiquantitative Parameters in PSMA-Targeted PET Imaging with [¹⁸F]DCFPyL: Intrapatient and Interpatient Variability of Normal Organ Uptake.

ABSTRACT:

Purpose

Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging has impacted the management of patients with prostate cancer (PCa) in many parts of the world. PSMA-targeted endoradiotherapies are also being increasingly utilized and for these applications, the radiopharmaceutical distribution in normal organs is particularly important because it may limit the dose that can be delivered to tumors. In this study, we measured both interpatient and intrapatient variability of [¹⁸F]DCFPyL uptake in the most relevant normal organs.

Procedures

Baseline and 6-month follow-up PSMA-targeted [¹⁸F]DCFPyL PET/computed tomography (CT) scans from 39 patients with PCa were reviewed. Volumes of interest were manually drawn using the

SUBMITTER: Sahakyan K 

PROVIDER: S-EPMC7955793 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature