11β-Hydroxylase (CYP11B1) gene variants and new-onset depression in later life.

ABSTRACT:

Background

Cumulative exposure to high glucocorticoid levels is detrimental for the brain and may have particular implications in later life. A feature of late-life depression is increased cortisol secretion. Variants in the CYP11B1 gene, which codes for the enzyme responsible for cortisol synthesis, could influence risk of late-life depression, but this hypothesis has not been examined. We investigated the associations between variants in the CYP11B1 gene and late-life depression, taking into account history of depression and potential sex-specific effects.

Methods

We assessed depression in 1007 community-dwellers aged 65 years or older (60% women) at baseline and over a 14-year follow-up. A clinical level of depression was defined as a score of ≥ 16 on the Centre for Epide

SUBMITTER: Ancelin ML 

PROVIDER: S-EPMC7955840 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature