Clinical value of DNA methylation markers in autoimmune rheumatic diseases.

ABSTRACT: Methylation of cytosine residues in DNA, the best studied epigenetic modification, is associated with gene transcription and nuclear organization, and ultimately the function of a cell. DNA methylation can be influenced by various factors, including changes in neighbouring genomic sites such as those induced by transcription factor binding. The DNA methylation profiles in relevant cell types are altered in most human diseases compared with the healthy state. Given the physical stability of DNA and methylated DNA compared with other epigenetic modifications, DNA methylation is an ideal marker for clinical purposes. However, few DNA methylation-based markers have made it into clinical practice, with the notable exception of some markers used in the field of oncology. Autoimmune rheumatic dis

SUBMITTER: Ballestar E 

PROVIDER: S-EPMC7955859 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature