Antimalarial Drug Resistance and Implications for the WHO Global Technical Strategy.

ABSTRACT:

Purpose of review

Five years have passed since the World Health Organization released its Global Technical Strategy for Malaria (GTS). In that time, progress against malaria has plateaued. This review focuses on the implications of antimalarial drug resistance for the GTS and how interim progress in parasite genomics and antimalarial pharmacology offer a bulwark against it.

Recent findings

For the first time, drug resistance-conferring genes have been identified and validated before their global expansion in malaria parasite populations. More efficient methods for their detection and elaboration have been developed, although low-density infections and polyclonality remain a nuisance to be solved. Clinical trials of alternative regimens for multidrug-resistant malaria have de

SUBMITTER: Ippolito MM 

PROVIDER: S-EPMC7955901 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature