Molecular characteristic of treatment failure clinical isolates of Leishmania major.

ABSTRACT:

Background

Leishmaniasis is a prevalent tropical disease caused by more than 20 Leishmania species (Protozoa, Kinetoplastida and Trypanosomatidae). Among different clinical forms of the disease, cutaneous leishmaniasis is the most common form, with an annual 0.6-1 million new cases reported worldwide. This disease's standard treatment is pentavalent antimonial (Sb^V) that have been used successfully since the first half of the 20th century as a first-line drug. However, treatment failure is an increasing problem that is persistently reported from endemic areas. It is important to define and standardize tests for drug resistance in cutaneous leishmaniasis. Sb^V must be reduced to its trivalent active form (Sb^III). This reduction occurs within th

SUBMITTER: Eslami G 

PROVIDER: S-EPMC7956003 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature