Dataset Information

Circulating endothelial progenitor cells during pregnancy in multiple sclerosis.

ABSTRACT:

Background

Endothelial progenitor cells (EPCs) have been shown to increase during physiological pregnancy and are believed to play a fundamental role in the process of placentation. Reduced levels of EPCs during pregnancy have been associated with preeclampsia and miscarriage. Women with multiple sclerosis (MS) are not at increased risk of preeclampsia nor of general adverse obstetric outcome, in contrast with some other autoimmune diseases.

Objective

The aim of this study was to evaluate circulating EPCs levels in pregnant patients with MS.

Methods

CD34+ and CD133+ were longitudinally detected by flow cytometry in the maternal plasma of 29 healthy controls and 9 MS patients and in the cord blood of their newborns.